Glyburide

SKU: orb1227134

Description

Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. (In Vitro):Glibenclamide (Brown adipocytes; 10 μΜ; 1 day) has no effect on adipocyte differentiation. Glibenclamide (Ucp1-2A-GFP brown adipocyte) significantly increases UCP1 expression. Glibenclamide directly binds and blocks the SUR1 subunits of ATP-dependent potassium channels (KATP) and consequently increases insulin secretion from the pancreatic β cells. Glibenclamide interferes with mitochondrial bioenergy by permeating mitochondrial intima with Cl- and promoting mitochondrial net Cl-/K+ cotransport. Glibenclamide induced autophagy inhibits its insulin secretion-improving function in β cells.(In Vivo):Glibenclamide (2 mg/kg; p.o.) increases of insulin release and rapid drop of blood glucose level.Glibenclamide (50 μg/kg; p.o.) does not cause significant change, such as body weight or body composition.

Key Properties

• CAS Number: 10238-21-8
• MW: 494.01
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈ClN₃O₅S
• SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
• Target: Potassium Channel
• Solubility: DMSO: 99mg/ml(200.4 mM);Water: <1mg/ml;Ethanol: <1mg/ml

Bioactivity

• In Vivo:
  Animal model: Mice. Dosage: 2 mg/kg. Administration: p.o. Result: Increased of insulin release and rapid drop of blood glucose level.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glyburide | Glibenclamide | Micronase | Diabeta | HB-420 | HB419 | Maninil | Neogluconin

Quick Database Links

Gene Symbol

Potassium Channel