rac-trans-4-hydroxy Glyburide

SKU: orb1694447

Description

rac-trans-4-Hydroxy Glyburide is an active metabolite of glyburide, produced via CYP2C8/9 metabolism. It potently inhibits glyburide binding to SUR1/Kir6.2 (KATP channels) in rat brain synaptosomes, exhibiting IC50 values of 0.95 nM and 100 nM at high and low affinity sites, respectively. This compound is a valuable tool for in vitro pharmacological studies of sulfonylurea receptors and pancreatic beta-cell research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 23155-00-2
• MW: 510.0
• Formula: C₂₃H₂₈ClN₃O₆S
• SMILES: COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)N[C@H]1CC[C@H](O)CC1 |wU:27.28,wD:30.32,(-4,-25.41,;-4,-23.87,;-5.33,-23.1,;-6.67,-23.87,;-8,-23.1,;-8,-21.56,;-9.34,-20.79,;-6.67,-20.79,;-5.33,-21.56,;-4,-20.79,;-2.67,-21.56,;-4,-19.25,;-2.67,-18.48,;-2.67,-16.94,;-1.33,-16.17,;-1.33,-14.63,;,-13.86,;1.33,-14.63,;1.33,-16.17,;,-16.94,;2.67,-13.86,;1.9,-12.53,;3.44,-15.19,;4,-13.09,;5.33,-13.86,;5.33,-15.4,;6.67,-13.09,;8,-13.86,;9.34,-13.09,;10.67,-13.86,;10.67,-15.4,;12,-16.17,;9.34,-16.17,;8,-15.4,)|
• Target: Potassium Channel,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3082214