Glyburide

SKU: orb1307954

Description

Glibenclamide

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 10238-21-8
• MW: 494.01
• Purity: >98%
• Formula: C₂₃H₂₈ClN₃O₅S
• SMILES: C(NCCC1=CC=C(S(NC(NC2CCCCC2)=O)(=O)=O)C=C1)(=O)C3=C(OC)C=CC(Cl)=C3
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 2 mg/ml with warming).

Bioactivity

• In Vivo:
  Glyburide enhances the apparent affinity of scavenger receptor class B type I (SR-BI) for high-density lipoprotein (HDL) binding in insulin-secreting cells. It inhibits SR-BI-mediated selective lipid uptake and efflux, with potency similar to its inhibition of ABCA1 (IC50 approximately 275-300 mM). Regardless of the pre-existing relaxation level, Glyburide can also reverse the relaxation induced by pinacidil. At a concentration of 0.03 mM, Glyburide blocks ATP-modulated potassium channels in insulin-secreting cells. It causes a concentration-dependent increase in the IC50 values for BRL34915 and diazoxide, eliminating the relaxation response to minoxidil sulfate. Doses of Glyburide ranging from 10-500 nM proportionately inhibit the relaxation time brought about by potassium channel openers.
• In Vitro:
  Administered intravenously at a dose of 25 mg/kg, Glyburide increased sodium (Na) ion excretion by 350% one hour after treatment, without affecting potassium (K) ion excretion, glomerular filtration rate, mean arterial pressure, or heart rate. In awake rats subjected to a saline load, Glyburide dose-dependently increased urinary sodium excretion, while urinary potassium excretion remained largely unchanged.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glibenclamide

Compound Identifiers

PubChem CID

3488