Ginkgolide B

SKU: orb1305072

Description

Ginkgolide B (BN-52021) is a natural terpene lactone from Ginkgo biloba that acts as a platelet-activating factor receptor (PAFR) antagonist with an IC50 of 3.6 µM. It is widely used in pharmacological research to study inflammation, neuroprotection, and cardiovascular disorders in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 15291-77-7
• MW: 424.40
• Purity: 99.81% (May vary between batches)
• Formula: C₂₀H₂₄O₁₀
• SMILES: CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C33C(O)C(=O)OC3OC4(C(=O)O5)C12O
• Target: PAFR,Apoptosis,Endogenous Metabolite
• Solubility: DMSO:125.00 mg/mL (294.53 mM);Ethanol:10.60 mg/mL (24.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (4.71 mM)

Bioactivity

• Target IC50:
  PAF receptor:3.6 μM
• In Vivo:
  Ginkgolide B effectively inhibits platelet-activating factor (PAF) receptors. In cystic cells, it modifies the Ras/MAPK signaling pathway, inducing cell differentiation. In EPC cells, Ginkgolide B promotes cell proliferation and endothelial gene expression by inducing the phosphorylation of eNOS, Akt, and p38, significantly enhancing vascular endothelial growth factor (VEGF)-induced migration responses.
• In Vitro:
  Oral administration of Ginkgolide B (50 mg/kg) before ischemia notably reduces neuronal damage in the hippocampus of rats. In a mouse model of focal transient ischemia, a 30-minute pretreatment with Ginkgolide B (100 mg/kg, s.c.) diminishes the area of infarction. Additionally, in animals anesthetized with pentobarbital or ethyl carbamate, Ginkgolide B, administered either intravenously (1 mg/kg) or orally (10 mg/kg), inhibits bronchoconstriction and increases hematocrit.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BN52021, BN-52021, BN 52021, Apoptosis, PAFR, inhibit, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, Ginkgolide B

Compound Identifiers

PubChem CID

65243