Ginkgolide B

SKU: orb1305072

Description

Ginkgolide B

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 15291-77-7
• MW: 424.40
• Purity: 99.81%
• Formula: C₂₀H₂₄O₁₀
• SMILES: CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C33C(O)C(=O)OC3OC4(C(=O)O5)C12O
• Target: Endogenous Metabolite,Apoptosis,PAFR
• Solubility: DMSO:125.00 mg/mL (294.53 mM);Ethanol:10.60 mg/mL (24.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (4.71 mM)

Bioactivity

• Target IC50:
  PAF receptor:3.6 μM
• In Vivo:
  Ginkgolide B effectively inhibits platelet-activating factor (PAF) receptors. In cystic cells, it modifie the Ras/MAPK signaling pathway, inducing cell differentiation. In EPC cells, Ginkgolide B promotes cell proliferation and endothelial gene expression by inducin the phosphorylation of eNOS, Akt, and p38, significantly enhancing vascular endothelial growth factor (VEGF)-induced migration responses.
• In Vitro:
  Oral administration of Ginkgolide B (50 mg/kg) before ischemia notably reduces neuronal damage in the hippocampus of rats. In a mouse model of focal transient ischemia, a 30 minute pretreatment with Ginkgolide B (100 mg/kg, s.c.) diminishe the area of infarction. Additionally, in animals anesthetized with pentobarbital or ethyl carbamate, Ginkgolide B, administered either intravenously (1 mg/kg) or orally (10 mg/kg), inhibits bronchoconstriction and increases hematocrit.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

BN52021, BN-52021, BN 52021, Apoptosis, PAFR, inhibit, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, Ginkgolide B

Compound Identifiers

PubChem CID

65243