Ginkgolide J

SKU: orb1300170

Description

Ginkgolide J (BN 52024) is a neuroprotective agent that blocks Aβ(1-42)-mediated suppression of hippocampal LTP. This activity supports its research use in models of Alzheimer's disease and cognitive impairment, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 107438-79-9
• MW: 424.40
• Purity: 99.94%
• Formula: C₂₀H₂₄O₁₀
• SMILES: [H][C@]12C[C@]34[C@]5([H])OC(=O)C3(O[C@]3([H])OC(=O)[C@H](O)C43[C@@H]([C@H]5O)C(C)(C)C)[C@@]1(O)[C@H](C)C(=O)O2
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (4.71 mM);DMSO:60.00 mg/mL (141.38 mM)

Bioactivity

• In Vitro:
  A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta induced Inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neur Protective effect is attributed in large part to Ginkgolide J that completely replicate the effect o the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A bet.
• Cell Research:
  Hippocampal cultures were treated by adding 10 μM Aβ_1–42 in its oligomeric form with or without P8A, or alternatively with and without each of the individual ginkgolides and bilobalide (GA, GB, GC, GJ, BB). These compounds were dissolved in DMSO and added to the culture medium at a ratio of 1:1000 (v/v), yielding a 0.1% DMSO solution. After 24 hr, the number of viable cells was assessed by nuclear counting. In a separate set of experiments, viable cells were counted using the ethidium homodimer/calcein‑AM combination of vital dyes (LIVE/DEAD Viability/Cytotoxicity Kit for mammalian cells), according to the manufacturer’s instructions. Values represent the mean ± SEM of three consecutive experiments. Each experiment was performed in triplicate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

BN 52024, BN52024, BN-52024, 7-b-Hydroxyginkgolide A, 7-beta-Hydroxyginkgolide A, 7-β-Hydroxyginkgolide A, Inhibitor, Ginkgolide J, PDE, inhibit

Compound Identifiers

PubChem CID

131674019