Ginkgolide B

SKU: orb1222655

Description

Ginkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release.

Key Properties

• CAS Number: 15291-77-7
• MW: 424.4
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₄O₁₀
• SMILES: O1[C@H]2[C@@H](O)[C@]34[C@@H]5OC(=O)[C@]3(O[C@@H]3OC(=O)[C@H](O)[C@]43[C@H](C(C)(C)C)C5)[C@@]2(O)[C@H](C)C1=O
• Target: PAFR
• Solubility: DMSO : ≥ 30 mg/mL; 70.69 mM

Bioactivity

• In Vivo:
  Animal model: Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeks. Dosage: 20 mg/kg. Administration: Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days. Result: Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase-and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.
• In Vitro:
  Western blot analysis. Cell line: HUVECs. Concentration: 30, 60, 150 μM. Incubation time: 24 h. Result: Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α. RT-PCR Cell line: HUVECs. Concentration: 30, 60, 150 μM. Incubation time: 24, 48 h. Result: Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bilobalide B | Ginkgolide B | BN 52021

Quick Database Links

Gene Symbol

PAFR