FZD8 (N) Antibody, Rabbit Polyclonal

SKU: orb67041

Description

Rabbit polyclonal to FZD8.Frizzled-8 (FZD8) is a receptor for Wnt proteins, which belongs to the G-protein coupled receptorFz/Smo family. FZD8 is a component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-cateninsignaling through inducing aggregation of receptor-ligand complexes into ribosome-sizedsignalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveledproteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt targetgenes. A second signaling pathway involving PKC and calcium fluxes has been seen for some familymembers. FZD8 may be involved in transduction and intercellular transmission of polarity informationduring tissue morphogenesis and/or in differentiated tissues.

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human FZD8
• Molecular Weight: 73
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-FZD8 antibody,anti-Frizzled8 antibody,anti-Fz8 antibody,anti-hFz8 antibody

Western blot analysis of total cell extracts from human MCF7 using FZD8 antibody

Quick Database Links

UniProt

Q9H461