FERULIC ACID METHYL ESTER

SKU: orb1222956

Description

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.(In Vitro):Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs).Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.

Key Properties

• CAS Number: 2309-07-1
• MW: 208.21
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₂O₄
• SMILES: Oc1ccc(cc1OC)/C=C/C(=O)OC
• Target: Others
• Solubility: DMSO : ≥ 100 mg/mL480.28 mM; H2O : 2 mg/mL9.61 mM

Bioactivity

• In Vitro:
  Ferulic acid methyl ester (25 μg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h. Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 μg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 μg/mL, in primary bone marrow derived-macrophages (BMDMs). Ferulic acid methyl ester (25 μg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK. Cell Viability Assay Cell line: Primary bone marrow derived-macrophages (BMDMs)C oncentration: 25 μg/mL Incubation time: 6 h, 18 h, 48 h. Result: Showed no cytotoxic effects on BMDMs. Western blot analysis. Cell line: RAW 246.7 cells Concentration: 10 μg/mL and 25 μg/mL. Incubation time: For 1 h before stimulation with LPS. Result: Significantly suppressed COX-2 expression at 25 μg/mL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methyl ferulate

Quick Database Links

Gene Symbol

Others