FBXW7 (C) Antibody, Rabbit Polyclonal

SKU: orb131883

Description

Rabbit polyclonal to FBXW7. F-box/WD repeat-containing protein 7 (FBXW7) is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXW7 probably recognizes and binds to phosphorylated target proteins. Furthermore, FBXW7 is involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

Research Area

Epigenetics & Chromatin

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human
• Application Notes:
  WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human FBXW7.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human FBXW7
• Molecular Weight: 80
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti F-box/WD repeat-containing protein 7 antibody, anti Archipelago homolog antibody, anti hAgo antibody, anti F-box and WD-40 domaincontaining protein 7 antibody, anti F-box protein FBX30 antibody, anti SEL-10 antibody, anti hCdc4 antibody, anti FBW7 antibody, anti FBX30 antibody, anti SEL10 antibody

Quick Database Links

UniProt

Q969H0