Fatostatin

SKU: orb1222399

Description

Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.(In Vitro):Fatostatin hydrobromide (125B11 hydrobromide) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin hydrobromide inhibits insulin-induced adipogenesis of 3T3-L1 cells.(In Vivo):Fatostatin hydrobromide (125B11 hydrobromide) (30 mg/kg; 150 mL; i.p.; daily for 28 days) reduces adiposity, ameliorates fatty liver by reducing triglyceride (TG) storage, and lowers hyperglycemia in ob/ob mice.

Key Properties

• CAS Number: 298197-04-3
• MW: 375.33
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₈N₂S·HBr
• SMILES: Cc1ccc(cc1)c1csc(c2cc(CCC)ncc2)n1.Br
• Target: Cannabinoid Receptor
• Solubility: In Vitro: DMSO : 25 mg/mL (66.61 mM)

Bioactivity

• In Vivo:
  Animal model: Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J). Dosage: 30 mg/kg; 150 mL. Administration: i.p. injection; daily for 28 days. Result: Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
• In Vitro:
  Cell Proliferation Assay Cell line: DU-145 cells. Concentration: 0.1, 1 μM Incubation time: 3 days. Result: Impaired the IGF1-induced growth at an IC50 of 0.1 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cannabinoid Receptor