Fatostatin A

SKU: orb1218989

Description

Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.

Key Properties

• CAS Number: 125256-00-0
• MW: 294.41
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₈N₂S
• SMILES: CCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1
• Target: Lipid
• Solubility: DMSO: 70 mg/mL (237.76 mM)\nEthanol: 70 mg/mL (237.76 mM)\nWater: Insoluble

Bioactivity

• In Vivo:
  Animal model: Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J). Dosage: 30 mg/kg; 150 μL. Administration: i.p. injection; daily for 28 days. Result: Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
• In Vitro:
  Cell Proliferation Assay Cell line: DU-145 cells. Concentration: 0.1, 1 μM Incubation time: 3 days. Result: Impaired the IGF1-induced growth at an IC50 of 0.1 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

125B11

Quick Database Links

Gene Symbol

Lipid