Etacrynic acid

SKU: orb1224584

Description

A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.

Key Properties

• CAS Number: 58-54-8
• MW: 303.135
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₂Cl₂O₄
• SMILES: CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
• Target: MEK
• Solubility: Ethanol: 30 mg/mL; DMSO: 30 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Edecrin

Quick Database Links

Gene Symbol

MEK