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ERK1/2 inhibitor 9

SKU: orb2278806

Description

ERK1/2 Inhibitor 9 (Probe 1) is a covalent, sub-micromolar inhibitor effective in cellular models like A375 melanoma. When functionalized with TCO and Tz-Thalidomide, it forms an ERK-CLIPTAC for targeted protein degradation, enabling research into ERK pathway inhibition and proteolysis-targeting chimera (PROTAC) strategies in cancer studies.

Research Area

Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2169302-75-2
MW586.08
FormulaC31H32ClN7O3
SMILESO=C(OC1CCC=CCCC1)NCCC#CC2=NC=CC(=C2)NC3=NC=C(Cl)C(=N3)NC=4C=CC=CC4NC(=O)C=C
TargetERK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information