ERK-IN-3

SKU: orb1298335

Description

ERK-IN-3

Research Area

Signal Transduction

Key Properties

• CAS Number: 2055597-12-9
• MW: 473.93
• Purity: 99.76%
• Formula: C₂₂H₂₅ClFN₇O₂
• SMILES: Cc1cnc(NC2CCOCC2)nc1-n1cnc(c1)C(=O)N[C@H](CN)c1cc(F)cc(Cl)c1
• Target: ERK
• Solubility: DMSO:250 mg/mL (527.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.55 mM)

Bioactivity

• In Vivo:
  ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice that was well tolerated at efficacious doses.
• In Vitro:
  ERK-IN-3 shows single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines.ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates like RSK1, FRA1, and Elk1 in various cell lines.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ASN 007, ASN007, ASN-007, ASN007 free base, cancer, inhibit, Inhibitor, Extracellular signal regulated kinases, ERK IN 3, ERK1/2, ERK1, ERK2, ERKIN3, ERK-IN-3, ERK, RAS

Compound Identifiers

PubChem CID

124122366