Chrysosplenol D

SKU: orb1297425

Description

Chrysosplenol D is a natural flavonoid efflux pump inhibitor that restores susceptibility to antibiotics and antimalarials in resistant strains. Its ability to potentiate drug efficacy has been demonstrated in vitro against pathogens like Staphylococcus aureus and Plasmodium falciparum, supporting research in antimicrobial resistance and infectious disease.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 14965-20-9
• MW: 360.31
• Purity: 97.87% (May vary between batches)
• Formula: C₁₈H₁₆O₈
• SMILES: COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC
• Target: JNK|||IL Receptor|||NF-κB
• Solubility: DMSO:55 mg/mL (152.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM)

Bioactivity

• Target IC50:
  Viability:11.6 µM(MDA-MB-231 TNBC cells)
• In Vitro:
  Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, chrysosplenol-D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 x 10(-5)M against P. falciparum in vitro compared with an IC50 value of about 3 x 10(-8)M for purified artimisinin
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, Chrysosplenol D, cancer, anti-inflammatory, Apoptosis, antitrypanosomal, NFkB, NF-kB, NF-κB, NFκB, ILReceptor, inhibit, JNK, ERK1/2, IL Receptor, Inhibitor

Compound Identifiers

PubChem CID

5280699