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EGFR/ErbB2 Inhibitor

SKU: orb1218613

Description

EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively).

Research Area

Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

CAS Number179248-61-4
MW387.43
Purity>98% (HPLC)
FormulaC23H21N3O3
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC
TargetEGFR
SolubilityDMSO:10 mM

Bioactivity

In Vitro
EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Protocol Information

Available Sizes

Select a size below

5 mg
$ 460.00
10 mg
$ 710.00
25 mg
$ 1,160.00
50 mg
$ 1,620.00
100 mg
$ 2,180.00
500 mg
$ 4,330.00