EGFR/ErbB-2/ErbB-4 inhibitor-2

SKU: orb1306145

Description

This small molecule is a potent, cell-permeable dual inhibitor of EGFR and ErbB2 (HER2), with IC50 values of 20 nM and 79 nM, respectively. It is widely used in cancer research to study receptor tyrosine kinase signaling in both cellular assays and in vivo tumor models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 179248-61-4
• MW: 387.43
• Purity: 99.55% (May vary between batches)
• Formula: C₂₃H₂₁N₃O₃
• SMILES: COc1cc2ncnc(Nc3ccc(OCc4ccccc4)cc3)c2cc1OC
• Target: EGFR
• Solubility: DMSO:55 mg/mL (141.96 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (6.45 mM)

Bioactivity

• Target IC50:
  ERB4:1.91 μM|ErbB2:0.08 μM|EGFR:20 nM|c-ErbB2:79 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-ErbB2, ErbB4, EGFR, EGFR/ErbB 2/ErbB 4 inhibitor 2, EGFR/ErbB2 Inhibitor, EGFR/ErbB2/ErbB4 inhibitor2, EGFR/ErbB-2/ErbB-4 inhibitor-2, Epidermal growth factor receptor, ErbB2, ErbB-1, HER1, HN5, Inhibitor, inhibit

Compound Identifiers

PubChem CID

9843206