(E)-Cardamonin

SKU: orb1304760

Description

(E)-Cardamonin, also known as Alpinetin chalcone, is a natural chalconoid isolated from plants like Alpinia species. It acts as a novel and potent hTRPA1 channel antagonist (IC50 = 454 nM), making it a valuable research tool for studying pain, inflammation, and neurobiology in both in vitro and in vivo models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19309-14-9
• MW: 270.28
• Purity: 99.07%
• Formula: C₁₆H₁₄O₄
• SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C(OC)C=C(O)C=C2O
• Target: Apoptosis,TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (37 mM);DMSO:45 mg/mL (166.49 mM)

Bioactivity

• Target IC50:
  TRPA1 (human):454 nM
• In Vivo:
  Cardamonin (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
• In Vitro:
  Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
• Cell Research:
  HEK293 cells are treated with cardamonin (0-90 μM). The cells treated in the absence of the test compound are the negative control. After incubated for 24 h, Cell Titer-Glo reagent is added to the cells and Luminescence is acquired on the plate reader.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

hTRPA1 cation channel, (E) Cardamonin, (E)-Cardamomin, (E)-Cardamoni, (E)Cardamonin, (E)-Cardamonin, (E)-Alpinetin chalcone, Alpinetin chalcone, Apoptosis, Cardamomin, Cardamoni, Cardamonin, TRPChannel, TRP Channel, TRPVChannel, TRPV Channel

Compound Identifiers

PubChem CID

641785