Cardamonin

SKU: orb2567413

Description

Cardamonin is a bioactive chalcone from Alpiniae katsumadai with demonstrated anticancer, anti-inflammatory, and antidiabetic properties. It functions by inhibiting key pathways like mTOR, NF-κB, and STAT3, and is utilized in research models for breast cancer, acute kidney injury, and chronic renal fibrosis in both in vitro and in vivo studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 18956-16-6
• MW: 270.28
• Formula: C₁₆H₁₄O₄
• SMILES: O=C(C=CC=1C=CC=CC1)C=2C(O)=CC(O)=CC2OC
• Target: mTOR|||Wnt/beta-catenin|||TRP/TRPV Channel|||COX|||Akt|||STAT|||Antioxidant|||NF-κB
• Solubility: DMSO:100 mg/mL (369.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.8 mM)

Bioactivity

• In Vivo:
  The male C57BL/6 J mice (8 weeks old, 20–22 g). The Cardamonin treatment group (DOX + Cardamonin) was pretreated with Cardamonin (20, 40 or 80 mg/kg/day) by gavage, and mice were then intraperitoneal injected with DOX. Cardamonin does-dependently increased the body weight of mice challenged with DOX. We also found that the ratio of heart weight to body weight was markedly increased by DOX, which was, however, decreased by Cardamonin treatment in a dose-dependent manner.
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• In Vitro:
  The cell viabilities of H9C2 and HL-1 treated with different concentrations of Cardamonin (0, 1.5, 3.125, 6.25, 12.5, 25, 50 and 100 μM) for 24 h were not remarkably changed, suggesting that Cardamonin under the tested doses showed no significant cytotoxicity to cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

βcatenin, TRP Channel, TRPV Channel, TRPChannel, TRPVChannel, STAT3, Wnt/β-catenin, Wnt/betacatenin, Wnt, Wnt/b-catenin, COX-2, beta-catenin, betacatenin, Cardamomin, bcatenin, Antioxidant, Alpinetin chalcone, Akt, mTOR, NF-κB, NFκB, NFkB, NF-kB

Compound Identifiers

PubChem CID

154102