Cardamonin

SKU: orb2900672

Description

Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.

Key Properties

• CAS Number: 18956-16-6
• MW: 270.28
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₄O₄
• SMILES: O=C(C=CC=1C=CC=CC1)C=2C(O)=CC(O)=CC2OC
• Target: TRP/TRPV Channel
• Solubility: In Vitro: DMSO : 125 mg/mL (462.48 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice. Animal model: Male C57BL/6 J mice (8 weeks old, 20-22 g). Dosage: 20, 40 or 80 mg/kg. Administration: Oral gavage; 20, 40 or 80 mg/kg; once. Result: Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner. Animal model: Male C57BL/6 J mice (8 weeks old, 20-22 g). Dosage: 20, 40 or 80 mg/kg. Administration: Oral gavage; 20, 40 or 80 mg/kg; once. Result: Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
• In Vitro:
  Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth. Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein. Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation. Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells. Cell Viability Assay Cell line: AGS, MGC-803, BGC-823 cells. Concentration: 5, 10, 20, 30, 40 μM. Incubation time: 24 or 48 hours. Result: Inhibited cell growth in a concentration-dependent manner. Western blot analysis. Cell line: AGS, MGC-803, BGC-823 cells. Concentration: 10, 20, 30 μM. Incubation time: 24 or 48 hours. Result: Down-regulated Bcl-2, increased Bax protein expression, and increased the protein expression levels of Caspase-3. Western blot analysis. Cell line: AGS cells. Concentration: 10, 20, 30 μM. Incubation time: 24 or 48 hours. Result: Suppressed the phosphorylation level of STAT3. Western blot analysis. Cell line: HL-1 cells. Concentration: 0, 25, 50, 100 μM. Incubation time: 24 hours. Result: Showed anti-oxidant effects in doxorubicin-stimulated cardiomyocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TRP/TRPV Channel