DMD Antibody

SKU: orb1410542

Description

Mouse monoclonal antibody to Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy)

Research Area

Cardiovascular Research

Images & Validation

• Tested Applications: ELISA, IHC
• Reactivity: Human

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone No.: DMD/3676
• Immunogen: A recombinant fragment (around aa 114-263) of human DMD protein (exact sequence is proprietary)
• Target: DMD
• Source/Expression System: Bioreactor
• Molecular Weight: 427kDa
• Purification: Protein A
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% rAlbumin & 0.05% azide. Also available WITHOUT rAlbumin & azide at 1.0mg/ml.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMD; CMD3B; Duchenne muscular dystrophy (DMD); Dystrophin; Muscular dystrophy Duchenne and Becker types

Analysis of Protein Array containing more than 19000 full-length human proteins using Dystrophin-Monospecific Mouse Monoclonal Antibody (DMD/3676). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Formalin-fixed, paraffin-embedded human heart muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3676).

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3676).

SDS-PAGE Analysis of Purified Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3676). Confirmation of Purity and Integrity of Antibody.

Quick Database Links

Gene Symbol

DMD

UniProt

P11532