Dimethyl fumarate

SKU: orb1310560

Description

Dimethyl fumarate

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 624-49-7
• MW: 144.13
• Purity: 99.88%
• Formula: C₆H₈O₄
• SMILES: COC(=O)\C=C\C(=O)OC
• Target: Nrf2,Reactive Oxygen Species,HIV Protease,Autophagy,Endogenous Metabolite
• Solubility: 10% DMSO+90% Saline:1.5 mg/mL (10.41 mM);DMSO:40 mg/mL (277.53 mM);Ethanol:7.2 mg/mL (49.95 mM);5% DMSO+95% Saline:0.29 mg/mL (2.01 mM)

Bioactivity

• In Vivo:
  METHODS: To stud the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain o the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps musclee.
• In Vitro:
  METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 µM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. Results: Pre-incubation with 10 µM MMF Dimethyl fumarate for 24 h protected Primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 µM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. Results: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, Endogenous Metabolite, Inhibitor, Human immunodeficiency virus, HIVProtease, HIV Protease, HIV, neuroprotective, KEAP1-Nrf2, Keap1-Nrf2, inhibit, Autophagy, Antioxidant, anti-inflammatory, brain-penetrant, DMF, Dimethyl, Dimethyl fumarate, Dimethyl Fumarate, ROS, sclerosis, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

637568