Dimethyl fumarate

SKU: orb1224424

Description

Dimethyl fumarate (DMF;BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types; an effective novel treatment for multiple sclerosis; activates the Nrf2 pathway and has been identified as a nicotinic acid receptor agonist in vitro.Multiple Sclerosis Approved.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	624-49-7
MW	144.1253
Purity	>98% (HPLC)
Formula	C₆H₈O₄
SMILES	O=C(OC)/C=C/C(OC)=O
Target	Keap1-Nrf2
Solubility	DMSO: 9.6 mg/mL

Bioactivity

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In Vivo

Animal model: Male C57BL/6 mice (8-week-old). Dosage: 50 mg/kg. Administration: Oral gavage; daily; for 7 days. Result: Was shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes.

In Vitro

Cell Viability Assay Cell line: SGC-7901, HT29, HCT116 and CT26 cells. Concentration: 20 μM, 50 μM, 100 μM, 200 μM. Incubation time: 24 hours. Result: Reduced cell viability in SGC-7901, HT29, HCT116 and CT26 cancer cells. Western blot analysis. Cell line: CT26 cancer cells. Concentration: 100 μM. Incubation time: 3 hours, 6 hours, 12 hours, 24 hours. Result: Significantly activated JNK, p38 and ERK in CT26 cells after treatment from 3 to 24 h.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DMF | BG-12

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Gene Symbol

Keap1-Nrf2

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