DDR Inhibitor

SKU: orb1709908

Description

This small molecule is a potent and selective inhibitor of discoidin domain receptors (DDRs), exhibiting an IC50 of 3.3 nM for DDR2 and 53% inhibition of DDR1 at 1.5 nM. It is a valuable research tool for studying DDR signaling in fibrosis, cancer, and arthritis in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1644069-80-6
• MW: 417.44
• Purity: 99.61% (May vary between batches)
• Formula: C₂₃H₂₀FN₅O₂
• SMILES: Cc1ccc(CNC(=O)Nc2cccc(F)c2)cc1NC(=O)c1cnc2ccccn12
• Target: Discoidin Domain Receptor (DDR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.79 mM);DMSO:50 mg/mL (119.78 mM)

Bioactivity

• Target IC50:
  DDR2:3.3 nM |DDR1:1.5 nM (IC53)
• In Vitro:
  DDR inhibitor is an effective DDR inhibitor. The IC50 of DDR2 is 3.3 nM, which has 53% inhibition on DDR1 at 1.5 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DDR2, DDR Inhibitor, DDR1, DDR, Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, DiscoidinDomainReceptor(DDR)

Compound Identifiers

PubChem CID

86764579