WRG-28

SKU: orb1307604

Description

WRG-28 is a potent and selective allosteric inhibitor of Discoidin Domain Receptor 2 (DDR2), exhibiting an IC50 of 230 nM. It is a valuable chemical probe for investigating DDR2's role in fibrosis and oncology research, enabling both in vitro biochemical assays and in vivo disease model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1913291-02-7
• MW: 410.44
• Purity: 97.84%
• Formula: C₂₁H₁₈N₂O₅S
• SMILES: CCNS(=O)(=O)c1ccc(COc2ccc3nc4ccc(=O)cc4oc3c2)cc1
• Target: Discoidin Domain Receptor (DDR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM);DMSO:15 mg/mL (36.55 mM)

Bioactivity

• Target IC50:
  DDR2:230 nM (IC50)
• In Vitro:
  WRG-28 is a selective, extracellularly acting small molecule inhibitor of DDR2 that uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. By targeting DDR2, WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

rheumatoid arthritis, WRG 28, WRG28, WRG-28, breast cancer, DiscoidinDomainReceptor, Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor(DDR), 4T1 breast cancer cells, BT549, CAFs, joint destruction, inhibit, Inhibitor, HEK293, DDR2, DDR

Compound Identifiers

PubChem CID

139035038