VU6015929

SKU: orb1299436

Description

VU6015929 is a potent and selective small molecule inhibitor of DDR1 and DDR2, with IC50 values of 4.67 nM and 7.39 nM, respectively. This compound is a valuable research tool for investigating the roles of these receptors in fibrosis and cancer progression in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2442597-56-8
• MW: 485.43
• Purity: 97.07% (May vary between batches)
• Formula: C₂₄H₁₉F₄N₅O₂
• SMILES: Cn1ccc(n1)-c1cncc(CNc2cc(ccc2F)C(=O)Nc2cccc(OC(F)(F)F)c2)c1
• Target: Discoidin Domain Receptor (DDR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.3 mM);DMSO:250 mg/mL (515.01 mM)

Bioactivity

• Target IC50:
  DDR1:4.67 nM |DDR2:7.39 nM
• In Vitro:
  VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic therapy.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, DiscoidinDomainReceptor(DDR), DDR, DDR2, DDR1, VU 6015929, VU6015929, VU-6015929

Compound Identifiers

PubChem CID

145925694