CREB inhibitor

SKU: orb1221062

Description

666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).

Research Area

Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1433286-70-4
• MW: 620.52
• Purity: >98% (HPLC)
• Formula: C₃₃H₃₁Cl₂N₃O₅
• SMILES: Cl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
• Target: Epigenetic Reader Domain
• Solubility: DMSO: 60 mg/mL (96.7 mM)

Bioactivity

• In Vivo:
  Animal model: 1-month-old female nude mice with MDA-MB-231 or T47D cells. Dosage: 10 mg/kg. Administration: IP; once a week; for 11 weeks. Result: Played a good role in inhibiting the growth of breast cancer.
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• In Vitro:
  Cell Proliferation Assay Cell line: CTRL or MSN-overexpressing MDA-MB-231 cells. Concentration: 73 nM. Incubation time: For 12 hours. Result: Significantly blocked the cell proliferation caused by MSN overexpression. Western blot analysis. Cell line: NRCMs. Concentration: 1 μM. Incubation time: 2 hour (pretreated). Result: Effectively inhibited PE-induced CREB phosphorylation.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CREB inhibitor

Quick Database Links

Gene Symbol

Epigenetic Reader Domain