HDAC3 inhibitor PT3

SKU: orb2646990

Description

HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.PT3 upregulated H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells.PT3 significantly improved the discrimination index in C57/BL6 mice in the novel object recognition (NOR) model, significant increased in H3K9 acetylation in hippocampus.PT3 upregulated CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3.

Research Area

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2710273-81-5
• MW: 319.360482931137
• Purity: >98%
• Formula: C₁₈H₁₇N₅O
• SMILES: C1(C(NC2=CC=CC=C2N)=O)=NC=C(NCC2=CC=CC=C2)N=C1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155568230