Naphthol AS-E

SKU: orb1299442

Description

Naphthol AS-E (nAS-E) is a small molecule inhibitor that disrupts the KIX-KID protein interaction, thereby suppressing CREB-mediated gene transcription. It is used in biochemical and cellular research to study transcriptional regulation, with applications in both in vitro binding assays and cell-based studies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 92-78-4
• MW: 297.74
• Purity: 99.85% (May vary between batches)
• Formula: C₁₇H₁₂ClNO₂
• SMILES: Oc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1
• Target: Epigenetic Reader Domain,Histone Acetyltransferase
• Solubility: DMSO:2.98 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  c-Kit:2.26 μM (IC50)
• In Vivo:
  nAS-E could reverse bone loss induced by MDA-MB-231 tumour. These results suggest that small molecules targeting CREB-CBP interaction to inhibit CREB-mediated gene transcription might be a potential approach for the treatment of breast cancer bone metastasis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, HATs, HAT, HistoneAcetyltransferase, Histone Acetyltransferase, MCF-7, KIX-KID, inhibit, Naphthol AS E, Naphthol ASE, Naphthol AS-E, nAS-E, CBP, CREB, A549, cancer

Compound Identifiers

PubChem CID

66720