Corynoxine

SKU: orb1221215

Description

Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.

Key Properties

• CAS Number: 6877-32-3
• MW: 384.47
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₈N₂O₄
• SMILES: CC[C@@H]1CN2CC[C@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)C(=O)Nc1ccccc31
• Target: BACE
• Solubility: DMSO: 50 mg/mL;Ethanol: 50 mg/mL;Water: Insoluble

Bioactivity

• In Vivo:
  Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice. Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.
• In Vitro:
  Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner. Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction. Western blot analysis. Cell line: N2a and SH-SY5Y cells. Concentration: 6.25, 12.5, 25 μM Incubation time: 6, 12 hours. Result: Induced autophagy in neuronal cell lines.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BACE