Clopidogrel thiolactone

SKU: orb1689879

Description

Clopidogrel thiolactone

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1147350-75-1
• MW: 337.82
• Purity: 98.79%
• Formula: C₁₆H₁₆ClNO₃S
• SMILES: COC(=O)[C@@H](N1CCC2SC(=O)C=C2C1)c1ccccc1Cl
• Target: P2Y Receptor,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.92 mM);Ethanol:2 mg/mL (5.92 mM);DMSO:30 mg/mL (88.8 mM)

Bioactivity

• In Vivo:
  Clopidogrel thiolactone holds great promise as a more potent and a safer antiplatelet agent that might have the following advantages over clopidogrel: (1) no drug resistance for CYP2C19 poor metabolizers; (2) lower dose-related toxicity due to a much lower effective dose; (3) faster onset of action. Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) exhibits good biological availability and pharmacokinetic parameters.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clopidogrel thiolactone, 2-oxoclopidogrel, P2YReceptor, P2Y12, P2Y Receptor

Compound Identifiers

PubChem CID

56848893