Cisapride

SKU: orb1223954

Description

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system.

Key Properties

• CAS Number: 81098-60-4
• MW: 465.95
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₉ClFN₃O₄
• SMILES: O=C(N[C@H]1[C@@H](OC)CN(CCCOC2=CC=C(F)C=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
• Target: 5-HT Receptor
• Solubility: Water: 2.71 mg/L

Bioactivity

• In Vivo:
  Animal model: Male Wistar rats with trinitrobenzenesulfonic-acid-(TNBS) induced rat colitis. Dosage: 2 mg/kg (i.p.); 4 mg/kg, (oral administration). Administration: 2 mg/kg, intraperitoneal injection; 4 mg/kg, oral administration; once. Result: Showed severe and intense transmural inflammation and diffuse necrosis, inflammatory granulomas and submucosal neutrophils infiltration in colitis rat. Induced body weight loss.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Kaudalit | Kinestase | Prepulsid | Presid | Pridesia | Propulsid

Quick Database Links

Gene Symbol

5-HT Receptor