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CDK9 degrader-1

SKU: orb3027555

Description

CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 µM). It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 µM). CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

MW637.56
FormulaC32H34Cl2N6O4
SMILESClC1=CC=CC(Cl)=C1C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O
TargetCDK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information