CBP-IN-1

SKU: orb1219374

Description

CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.

Key Properties

• CAS Number: 2222941-37-7
• MW: 534.6
• Purity: >98% (HPLC)
• Formula: C₃₀H₃₂F₂N₄O₃
• SMILES: O=C1N(C2=CC=C(F)C(F)=C2)[C@H](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@H](OC)CC6)CCC1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:100 mg/mL (187.06 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Noncastrated male athymic nude mice. Dosage: 10-30 mg/kg. Administration: Oral gavage; at 10 or 20 mg/kg daily (QD) or at 30 mg/kg every other day (QOD) for 28 days. Result: Affected tumor growth at 10 mg/kg daily, 20 mg/kg daily, and 30 mg/kg every other day.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain