Calcimycin

SKU: orb1219630

Description

Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage.

Key Properties

• CAS Number: 52665-69-7
• MW: 523.62
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₇N₃O₆
• SMILES: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c1ccc[nH]1
• Target: Antibacterial
• Solubility: DMSO:47 mg/mL (89.76mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Mice (ICR, 25-30 g). Dosage: 2.5 or 7.5 nM. Administration: Intrapleurally. Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A-23187,Antibiotic A-23187

Quick Database Links

Gene Symbol

Antibacterial