Calcimycin hemimagnesium

SKU: orb1981786

Description

Calcimycin (A-23187) hemimagnesium, an antibiotic and divalent cation ionophore (such as calcium and magnesium), serves various biological roles. It triggers Ca2+-dependent cell death by elevating intracellular calcium levels and suppresses the growth of Gram-positive bacteria and certain fungi. Additionally, this compound hinders ATPase activity and uncouples oxidative phosphorylation (OXPHOS) in mammalian cells, ultimately leading to apoptosis.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	72124-77-7
MW	1069.53
Formula	C₅₈H₇₂MgN₆O₁₂
SMILES	O=C1[O-][Mg+2]234([N]=5C=6C(C(=O)[O-]2)=C(NC)C=CC6OC5CC7OC8(OC(C(C)C(=O3)C9=CC=CN9)C(C)CC8C)CCC7C)[N]=%10C=%11C1=C(NC)C=CC%11OC%10CC%12OC%13(OC(C(C)C(=O4)C%14=CC=CN%14)C(C)CC%13C)CCC%12C
Target	Antifungal,Apoptosis,Autophagy,OXPHOS,Others,Antibacterial

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Antifungal,Apoptosis,Autophagy,OXPHOS,Others,Antibacterial

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