CA-4948

SKU: orb1225891

Description

CA-4948 (AU-4948) is a novel potent, selective, orally bioavailable IRAK4 inhibitor; shows in vivo activity in TLR4-induced cytokine release model, exhibits dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models; a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling, induces tumor regression in an ABC-DLBCL xenograft model combined with Venetoclax.Blood Cancer Phase 1 Clinical(In Vitro):IRAK4-IN-7 has anti-cancer and anti-inflammatory activities, it can be used for cancer and inflammatory diseases treatment.

Key Properties

• CAS Number: 1801343-74-7
• MW: 417.429
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₉N₇O₃
• SMILES: O=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3
• Target: IRAK
• Solubility: DMSO : 13.89 mg/mL 33.28 mM;H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  IRAK4-IN-7 has anti-cancer and anti-inflammatory activities, it can be used for cancer and inflammatory diseases treatment.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CA 4948 | CA4948 | AU-4948 | AU 4948 | AU4948

Quick Database Links

Gene Symbol

IRAK