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BPR1J-097

SKU: orb1305836

Description

BPR1J-097 is a potent and selective small molecule inhibitor of FLT-3, demonstrating an IC50 of 11±7 nM against the wild-type kinase and 3 nM against the D835Y mutant. It exhibits significant anti-leukemic activity in cellular assays and has shown promising efficacy in preclinical in vivo models of FLT3-ITD-driven acute myeloid leukemia.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1327167-19-0
MW516.61
Purity99.30% (May vary between batches)
FormulaC27H28N6O3S
SMILESCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1cc([nH]n1)-c1cccc(NS(=O)(=O)c2ccccc2)c1
TargetFLT
SolubilityDMSO:11 mg/mL (21.29 mM)

Bioactivity

Target IC50
FLT3:11±7 nM|FLT3 (D835Y):3 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cluster of differentiation antigen 135, CD135, BPR1J 097, BPR1J097, BPR-1J-097, BPR1J-097, Fms like tyrosine kinase 3, FLT3, Inhibitor, inhibit

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 80.00
10 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
25 mg
$ 190.00
50 mg
$ 290.00
100 mg
$ 400.00
DispatchUsually dispatched within 5-10 working days
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