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BPR1J-097

SKU: orb1223344

Description

BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. BPR1J-097 may be useful in AML treatments.IC50 of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC(50)s) were 21 ±7 and 46 ±14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.

Images & Validation

Key Properties

CAS Number1327167-19-0
MW516.62
Purity>98% (HPLC)
FormulaC27H28N6O3S
SMILESCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c(c1)c1cc(ccc1)NS(=O)(=O)c1ccccc1
TargetEGFR

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BPR1J097 | BPR1J-097 | BPR1J 097

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Protocol Information

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 120.00
10 mg
$ 190.00
25 mg
$ 380.00
50 mg
$ 640.00
100 mg
$ 910.00