BPR1J-097 hydrochloride (1327167-19-0(free base))

SKU: orb1303012

Description

BPR1J-097 is a potent and novel small molecule inhibitor of FLT-3 with an IC50 of 11±7 nM. It demonstrates significant anti-tumor efficacy in vivo, making it a valuable chemical probe for oncology research targeting FLT-3-dependent cancers in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 553.07
• Purity: 98.73% (May vary between batches)
• Formula: C₂₇H₂₉ClN₆O₃S
• SMILES: Cl.CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1cc([nH]n1)-c1cccc(NS(=O)(=O)c2ccccc2)c1
• Target: FLT
• Solubility: DMSO:5.54 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  MOLM-13 and MV4-11 cells:21±7 and 46±14 nM|FLT3 (D835Y):3 nM|FLT3:11±7 Nm
• In Vivo:
  In FLT3-driven AML murine xenograft models, BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells and pronounced dose-dependent tumour growth inhibition and regression.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BPR1J 097 hydrochloride (1327167 19 0(free base)), BPR1J097 hydrochloride (1327167190(free base)), BPR-1J-097 hydrochloride (1327167-19-0(free base)), BPR1J-097 hydrochloride (1327167-19-0(free base)), FLT3

Compound Identifiers

PubChem CID

132472229