BMS-309403

SKU: orb1302779

Description

BMS309403 is a potent, selective inhibitor of adipocyte fatty acid binding protein (aFABP) that competitively occupies its fatty acid binding pocket. It has demonstrated efficacy in improving endothelial function in both apolipoprotein E-deficient mouse models and cultured human endothelial cells, supporting research in metabolic and cardiovascular diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 300657-03-8
• MW: 474.55
• Purity: >98%
• Formula: C₃₁H₂₆N₂O₃
• SMILES: CCc1c(c(nn1-c1ccccc1-c1cccc(OCC(O)=O)c1)-c1ccccc1)-c1ccccc1
• Target: FABP (Fatty acid binding protein)
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

• Target IC50:
  FABP5: 350 nM |FABP3: 250 nM |FABP4:< 2 nM
• In Vivo:
  METHODS: 3 weeks after the onset of diabetes, mice were orally treated with BMS309403 (40 mg/kg, daily) for 3 weeks. During treatment, monitor blood sugar levels. RESULTS BMS309403 can significantly reduce the protein expression of FABP4 in mouse retinal tissue and partially reduce blood glucose levels in mice.
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• In Vitro:
  Treatment with BMS309403 significantly reduced MCP-1 production in THP-1 macrophages in a dose- and time-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS309403, BMS-309403, BMS 309403, endothelial, FABP, FABP3, FABP5, FABP4, Fatty acid-binding protein, function, glucose, inhibit, Inhibitor, oral, selective, uptake

Compound Identifiers

PubChem CID

16122583