BMS-309403

SKU: orb1225393

Description

A potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM; improves endothelial function, phosphorylated and total eNOS and reduces plasma triglyceride levels but does not affect endothelium-independent relaxations in mice; exhibits an effective therapeutic activity against severe atherosclerosis and type 2 diabetes in mouse models.

Key Properties

• CAS Number: 300657-03-8
• MW: 474.55
• Purity: >98% (HPLC)
• Formula: C₃₁H₂₆N₂O₃
• SMILES: CCc1c(c(nn1c2ccccc2c3cccc(c3)OCC(=O)O)c4ccccc4)c5ccccc5
• Target: FABP
• Solubility: 100 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: C57BL/6J mice (ApoE / mice). Dosage: 15 mg/kg. Administration: Chronic treatment; daily for 6 weeks. Result: Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE / mice.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS309403

Quick Database Links

Gene Symbol

FABP