BI-2852

SKU: orb1710263

Description

BI-2852 is a potent, nanomolar-affinity small molecule inhibitor targeting the KRAS switch I/II pocket. It effectively blocks downstream signaling pathways and demonstrates antiproliferative activity in KRAS-mutant cell lines, making it a valuable tool for in vitro oncology research and signaling studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2375482-51-0
• MW: 516.59
• Purity: 98.98% (May vary between batches)
• Formula: C₃₁H₂₈N₆O₂
• SMILES: Cn1cnc(Cn2ccc3ccc(CNCc4[nH]c5ccccc5c4[C@H]4NC(=O)c5ccc(O)cc45)cc23)c1
• Target: Kras,Ras
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.87 mM);DMSO:55 mg/mL (106.47 mM)

Bioactivity

• Target IC50:
  KRas (G12C):450 nM|KRas (G12C):750 nM (kd)
• In Vitro:
  BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, KRAS G12C, BI2852, BI-2852, BI 2852, Ras

Compound Identifiers

PubChem CID

138756246