BI 2852 FL

SKU: orb3027405

Description

BI 2852 FL is a cell-permeable bioluminescence resonance energy transfer (BRET) fluorescent probe targeting the pan-RAS type. It is synthesized by conjugating a fluorophore with a derivative of the reversible SI/II-P KRAS inhibitor, BI 2852. BI 2852 FL is employed in a competitive BRET format to quantify the binding of SII-P to multimeric RAS complexes within living cells.

Research Area

Signal Transduction

Key Properties

• Target: Ras,Kras
• Molecular Weight: 1088.02
• CAS Number: 2762758-95-0
• Formula: C₅₉H₆₄BF₂N₁₁O₇
• SMILES: O=C1NC(C2=C(CNCC3=CC4=C(C=CN4CC5=NC=CN5CCCCC(NCCOCCOCCOCCNC(CCC6=CC=C7C=C8C=CC(C9=CC=CN9)=[N+]8[B-](F)(N76)F)=O)=O)C=C3)NC%10=C2C=CC=C%10)C%11=CC(O)=CC=C1%11

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras,Kras