Betaine chloride

SKU: orb1311015

Description

Betaine chloride

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 590-46-5
• MW: 153.61
• Purity: ≥95% (May vary between batches)
• Formula: C₅H₁₂ClNO₂
• SMILES: [Cl-].C[N+](C)(C)CC(O)=O
• Target: Endogenous Metabolite,Chloride channel
• Solubility: H2O:43 mg/mL (279.93 mM)

Bioactivity

• In Vitro:
  Exposure to increasing levels of Betaine hydrochloride significantly inhibits HeLa cell proliferation, as demonstrated by the MTT assay (p<0.05). The S phase cell percentage is notably higher in groups exposed to doses below 5 mg/mL compared to those subjected to higher doses, whereas Sub-G1 phase rates exhibit the reverse trend (p<0.05). Concentrations of Betaine hydrochloride above 5.0 mg/mL markedly induce apoptosis in HeLa cells (p<0.01). Superoxide dismutase (SOD) activity in low dose groups slightly exceeds that of the control group (p<0.05). Additionally, there's a noticeable synchrony and correlation in the expression levels of pro-apoptotic genes (Bax, P53, Caspase 3) and the anti-apoptotic gene (Bcl-2). Furthermore, upon inducing apoptosis signals, p53 and cyclin D1 are activated, potentially halting the cell cycle at either the G1/S or S/G2 checkpoints.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Glycine betaine-binding periplasmic protein, Inhibitor, inhibit, Circadian clock protein KaiB, Chloridechannel, Chloride channel, Betaine, Betaine chloride, Betaine Chloride, Betaine hydrochloride, Betaine Hydrochloride

Compound Identifiers

PubChem CID

11545