Bay K 8644

SKU: orb1300476

Description

Bay K 8644 (SQ 28,873) is a selective L-type calcium channel agonist with an IC50 of 17.3 nM. It is widely used in cardiovascular and neuropharmacology research to study calcium signaling in both in vitro cellular assays and in vivo animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 71145-03-4
• MW: 356.3
• Purity: 99.97% (May vary between batches)
• Formula: C₁₆H₁₅F₃N₂O₄
• SMILES: COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1C(F)(F)F)[N+]([O-])=O
• Target: Calcium Channel
• Solubility: Ethanol:35.6 mg/mL (99.92 mM);H2O:< 1 mg/mL (insoluble);DMSO:83.33 mg/mL (233.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.81 mM)

Bioactivity

• Target IC50:
  Ca2+ channel, L-type:17.3nM(EC50)
• In Vivo:
  Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.
• In Vitro:
  Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(±)-BAY-K-8644, (±)-Bay K 8644, Bay K 8644, Bay K8644, Bay K-8644, CalciumChannel, Calcium Channel, Ca2+ channels, Ca2+, Ca channels, BAY-K 8644, BAY-K8644, BAY-K-8644, L-type calcium channel, L-type, inhibit, influx, Inhibitor, sarcolemmal, SQ 28,873

Compound Identifiers

PubChem CID

2303