(R)-(+)-Bay-K-8644

SKU: orb1679037

Description

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor that suppresses Ba2+ currents and acts as a competitive thromboxane A2 receptor antagonist. It is utilized in cardiovascular and neuropharmacology research, including studies of respiratory depression in vivo and platelet activation in vitro.

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 98791-67-4
• MW: 356.3
• Purity: 96.57% (May vary between batches)
• Formula: C₁₆H₁₅F₃N₂O₄
• SMILES: COC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
• Target: PPAR,Calcium Channel
• Solubility: DMSO:100 mg/mL (280.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.23 mM)

Bioactivity

• Target IC50:
  Iba:957 nM
• In Vitro:
  (R)-(+)-Bay-K-8644, a component of the racemic mixture Bay K 8644, is a well-known L-type Ca2+ channel agonist but functions as an inhibitor of Ba2+ currents (IBa) with an IC50 of 975 nM. At a concentration of 0.5 μM, it reduces IBa to 71±10% of the control level, demonstrating its efficacy in inhibiting Ba2+ currents. Notably, this compound acts as a calcium channel inhibitor, crucial for modulating calcium channel activity .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-(+)-Bay K 8644, (R)(+)BayK8644, (R) (+) Bay K 8644, CalciumChannel, Calcium Channel, Bay-K 8644, Bay-K8644, Bay-K-8644, Bay K 8644, Bay K8644, Bay K-8644, L-type calcium channel, TXA2R

Compound Identifiers

PubChem CID

6604881