(S)-(-)-Bay-K-8644

SKU: orb1296175

Description

(S)-(-)-Bay-K-8644

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 98625-26-4
• MW: 356.3
• Purity: 99.37%
• Formula: C₁₆H₁₅F₃N₂O₄
• SMILES: COC(=O)C1=C(C)NC(C)=C([C@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
• Target: Calcium Channel
• Solubility: DMSO:120 mg/mL (336.79 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.23 mM)

Bioactivity

• Target IC50:
  Ba2+ current:32 nM (EC50)
• In Vitro:
  The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50: 14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth musclee cells but effectively blocks further stimulation by 1 μM FPL 64176. (S)-(-)-Bay-K-8644 can preven the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes o the guinea pig antrum.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, L-type calcium channel, CalciumChannel, Bay K 8644, Bay K8644, Bay K-8644, Bay-K 8644, Bay-K8644, Bay-K-8644, Ca channels, Ca2+ channels, Calcium Channel, (S) ( ) Bay K 8644, (S)-(-)-Bay K 8644, (S)()BayK8644

Compound Identifiers

PubChem CID

6603728