Auristatin F

SKU: orb1308626

Description

Auristatin F is a potent microtubule-disrupting agent and vascular damaging compound. It serves as a highly effective cytotoxic payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy, with applications in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 163768-50-1
• MW: 745.99
• Purity: 99.25% (May vary between batches)
• Formula: C₄₀H₆₇N₅O₈
• SMILES: [C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)N(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Target: Microtubule Associated,ADC Cytotoxin
• Solubility: DMSO:195 mg/mL (261.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.7 mM)

Bioactivity

• In Vitro:
  Auristatin F and Monomethyl Auristatin F (MMAF) are highly potent cytotoxic agents utilized in ADCs.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Conjugate, cytotoxin, damaging, ADC Cytotoxin, ADCCytotoxin, ADC Payload, agent, Auristatin F, inhibitor, inhibit, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, microtubule, Microtubule, VDA, vascular

Compound Identifiers

PubChem CID

67472795