AS-99

SKU: orb1744093

Description

AS-99 is a potent and selective first-in-class inhibitor of the ASH1L histone methyltransferase, demonstrating anti-leukemic activity. It inhibits proliferation and induces apoptosis in vitro, while effectively reducing leukemia burden in vivo by downregulating critical MLL fusion oncogene targets.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• MW: 630.14
• Formula: C₂₇H₃₁ClF₃N₅O₃S₂
• SMILES: CN1CC(C(NCC2=CC3=C(C(C4=CC(C(N)=S)=CC=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5)C=C2)=O)C1.Cl
• Target: Apoptosis,Others,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162641001